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J Acquir Immune Defic Syndr. 2014 Dec 15;67(5):573-5. doi: 10.1097/QAI.0000000000000353.

The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women.

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*Wellcome Trust Centre for Human Genetics Jenner Institute-Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; †Department of Obstetrics and Gynaecology, Center for the AIDS Programme of Research in South Africa, and Women's Health and HIV Research Unit, University of KwaZulu Natal, Durban, South Africa; ‡University of Zimbabwe College of Medicine Harare, Harare, Zimbabwe; §Department of Obstetrics and Gynaecology, Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda; ‖Department of Paediatrics, Makerere University, Kampala, Uganda; ¶Department of Paediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; #FHI 360, Research Triangle Park, School of Medicine, Durham, NC; **School of Medicine, Johns Hopkins University, Baltimore, MD; and ††Maternal Adolescent and Child Health, University of the Witwatersrand, Johannesburg, South Africa.


Recent human studies support historical animal studies that suggested an association between peripheral blood monocyte:lymphocyte (ML) ratio and tuberculosis (TB) disease. To evaluate generalizability of this finding, we modeled the association between peripartum ML ratio and incident TB disease within 18 months postpartum among 1202 HIV-infected women in South Africa, Tanzania, Uganda, and Zimbabwe. The ML ratio was associated with increased risk of TB disease independently to combination antiretroviral therapy, World Health Organization stage, or CD4 count (adjusted hazard ratio = 1.22, 95% confidence interval: 1.07 to 1.4, P = 0.003 per 0.1 unit increase in ML ratio).

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