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Biomed Res Int. 2014;2014:960395. doi: 10.1155/2014/960395. Epub 2014 Aug 28.

Altered regional homogeneity in rolandic epilepsy: a resting-state FMRI study.

Author information

1
Department of Neurology, the Second Affiliated Hospital of Medial College, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, China.
2
Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.
3
Department of Neurology, the Second Affiliated Hospital of Medial College, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, China ; Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 310015, China.

Abstract

Children with rolandic epilepsy (RE) are often associated with cognitive deficits and behavioral problems. Findings from neurophysiological and neuroimaging studies in RE have now demonstrated dysfunction not only in rolandic focus, but also in distant neuronal circuits. Little is known, however, about whether there is distributed abnormal spontaneous brain activity in RE. Using resting-state functional magnetic resonance imaging (RS-fMRI), the present study aimed to determine whether children with RE show abnormal local synchronization during resting state and, if so, whether these changes could be associated with the behavioral/clinical characteristics of RE. Regional homogeneity (ReHo) in children with RE (n = 30) and healthy children (n = 20) was computed on resting-state functional MRI data. In comparison with healthy children, children with RE showed increased ReHo in the central, premotor, and prefrontal regions, while they showed decreased ReHo in bilateral orbitofrontal cortex and temporal pole. In addition, the ReHo value in the left orbitofrontal cortex negatively was corrected with performance intelligence quotient in the children with RE. The aberrant local synchronization, not strictly related to primary site of the typical rolandic focus, indicates the neuropathophysiological mechanism of RE. The study findings may shed new light on the understanding of neural correlation of neuropsychological deficiencies in the children with RE.

PMID:
25247197
PMCID:
PMC4163434
DOI:
10.1155/2014/960395
[Indexed for MEDLINE]
Free PMC Article

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