blaNDM-5 carried by an IncX3 plasmid in Escherichia coli sequence type 167

Antimicrob Agents Chemother. 2014 Dec;58(12):7548-52. doi: 10.1128/AAC.03911-14. Epub 2014 Sep 22.

Abstract

bla(NDM-)5 was found in Escherichia coli strain 0215 from a Chinese patient without travel history. Genomic sequencing and conjugation experiments were performed. Strain 0215 belonged to sequence type 167 (ST167) and had other resistance determinants, including bla(TEM-135), bla(CTX-M-14), and aac(6')-Ib. bla(NDM-5) was carried by a 47-kb self-transmissible IncX3 plasmid and was in a complex genetic context similar to that of bla(NDM-1) on IncX3 plasmids. IncX3 plasmids might have emerged as a common vehicle mediating the spread of bla(NDM).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Asian People
  • Conjugation, Genetic
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Escherichia coli / growth & development
  • Escherichia coli Infections / diagnosis
  • Escherichia coli Infections / microbiology
  • Genome, Bacterial*
  • Genotype
  • Humans
  • Male
  • Plasmids / chemistry*
  • Plasmids / metabolism
  • Sequence Analysis, DNA
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • beta-Lactams
  • beta-Lactamases

Associated data

  • BioProject/PRJNA244631