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J Comp Pathol. 2014 Nov;151(4):375-9. doi: 10.1016/j.jcpa.2014.08.002. Epub 2014 Sep 20.

Bilaterally symmetric focal cortical dysplasia in a golden retriever dog.

Author information

1
Department of Pathology, Microbiology and Immunology, Veterinary Medical Teaching Hospital, University of California - Davis, CA, USA.
2
Department of Pathology, University of California - San Francisco, San Francisco, CA, USA.
3
Department of Radiology and Small Animal Medicine, Veterinary Medical Teaching Hospital, University of California - Davis, CA, USA.
4
Department of Pathology, Microbiology and Immunology, Veterinary Medical Teaching Hospital, University of California - Davis, CA, USA. Electronic address: ssiso@ucdavis.edu.

Abstract

A 10-year-old golden retriever dog was referred with a 24-h history of generalized seizures. Magnetic resonance imaging of the brain found no abnormalities on 3 mm transverse sections and the dog was subsequently humanely destroyed. Microscopically there was bilaterally symmetrical focal disorganization of cortical grey matter within the tips of the right and left suprasylvian gyri of the temporal cortex. The focal abnormal cortical lamination was characterized by loss of pyramidal neurons with abnormal, irregular, angular, remaining neurons occasionally forming clusters, surrounded by fibrillary astrogliosis and microgliosis and vascular proliferation. These histological findings are consistent with focal cortical dysplasia, a cerebral cortical malformation that causes seizures in people, but not reported previously in the dog.

KEYWORDS:

dog; focal cortical dysplasia

PMID:
25246180
DOI:
10.1016/j.jcpa.2014.08.002
[Indexed for MEDLINE]

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