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Drug Discov Today. 2015 Jan;20(1):156-64. doi: 10.1016/j.drudis.2014.09.008. Epub 2014 Sep 20.

Slit/Robo pathway: a promising therapeutic target for cancer.

Author information

1
Department of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
2
Department of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: mjaggi@uthsc.edu.
3
Department of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: schauha1@uthsc.edu.

Abstract

Axon guidance molecules, slit glycoprotein (Slit) and Roundabout receptor (Robo), have implications in the regulation of physiological processes. Recent studies indicate that Slit and Robo also have important roles in tumorigenesis, cancer progression and metastasis. The Slit/Robo pathway can be considered a master regulator for multiple oncogenic signaling pathways. Herein, we provide a comprehensive review on the role of these molecules and their associated signaling pathways in cancer progression and metastasis. Overall, the current available data suggest that the Slit/Robo pathway could be a promising target for development of anticancer drugs.

PMID:
25245168
PMCID:
PMC4445861
DOI:
10.1016/j.drudis.2014.09.008
[Indexed for MEDLINE]
Free PMC Article

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