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Cancer Genet. 2014 Sep;207(9):434-6. doi: 10.1016/j.cancergen.2014.07.001. Epub 2014 Jul 18.

Malignant rhabdoid tumor of the kidney: significantly improved response to pre-operative treatment intensified with doxorubicin.

Author information

1
Saarland University Hospital, Pediatric Hematology and Oncology, Homburg/Saar, Germany. Electronic address: rhoikos.furtwaengler@uks.eu.
2
Saarland University Hospital, Pediatric Hematology and Oncology, Homburg/Saar, Germany.
3
Pediatric Pathology, Schleswig-Holstein University Hospital, Campus Kiel, Kiel, Germany.
4
Children's Hospital Zurich, University of Zurich, Section of Pediatric Oncology, Zurich, Switzerland.
5
St. Anna Children's Hospital, Vienna University Hospital, Vienna, Austria.
6
Pediatric Hematology and Oncology, University Hospital, Tübingen, Germany.
7
Swabian Children's Cancer Center, Children's Hospital Augsburg, Augsburg, Germany.

Abstract

Case reports and in vitro testing suggest sensitivity of malignant rhabdoid tumor of the kidney (MRTK) to anthracyclines. Prospective study data supporting doxorubicin's efficacy is lacking. We compared the change of tumor volume in the kidney to upfront treatment with either actinomycin D and vincristine (AV) or doxorubicin-intensified AV (AVD) in all patients with MRTK, who had been treated from 1991-2013 in Austria, Switzerland, and Germany in the framework of three prospective Société International d'Oncologie Pédiatrique/Gesellschaft für Pädiatrische Onkologie und Hämatologie nephroblastoma studies. A total of 37 patients with MRTK received pre-operative chemotherapy (AV, n = 19; AVD, n = 18). Initial and tumor volume after pre-operative treatment was reported in all patients who received AV and 15 of 18 (83%) patients who received AVD. Mean tumor volume at diagnosis was 247 (±48) mL in the AV cohort and 345 (±47) mL in the AVD cohort. Mean volume at surgery was 249 (±46) mL and 137 (±27) mL, respectively. Relative change in tumor volume was +19 (±16)% in patients who received AV and -63 (±26)% in patients who received AVD (P < 0.001). Change in volume to AV ranged from -60 to +224%, whereas the change to AVD ranged from -9 to -92%. We provide good evidence of doxorubicin's activity in MRTK in vivo by demonstrating a significantly better response to neoadjuvant AVD compared with AV alone.

KEYWORDS:

Doxorubicin; childhood renal tumor; response; rhabdoid tumor; upfront chemotherapy

PMID:
25242089
DOI:
10.1016/j.cancergen.2014.07.001
[Indexed for MEDLINE]

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