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Biochim Biophys Acta. 2015 Jun;1851(6):844-56. doi: 10.1016/j.bbalip.2014.09.010. Epub 2014 Sep 18.

Phosphoinositides regulate ion channels.

Author information

1
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195-7290, USA. Electronic address: hille@u.washington.edu.
2
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195-7290, USA. Electronic address: dickson2@u.washington.edu.
3
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195-7290, USA. Electronic address: mkruse@u.washington.edu.
4
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195-7290, USA. Electronic address: vivas@u.washington.edu.
5
Department of Brain Science, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Republic of Korea. Electronic address: bcsuh@dgist.ac.kr.

Abstract

Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. This article is part of a Special Issue entitled Phosphoinositides.

KEYWORDS:

Calcium channel; G-protein coupled receptor (GPCR); Phosphatidylinositol 4,5-bisphosphate; Phospholipase C (PLC); Potassium channel; Transient receptor potential channel (TRP channel)

PMID:
25241941
PMCID:
PMC4364932
DOI:
10.1016/j.bbalip.2014.09.010
[Indexed for MEDLINE]
Free PMC Article
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