Format

Send to

Choose Destination
Food Chem Toxicol. 2014 Dec;74:60-7. doi: 10.1016/j.fct.2014.08.018. Epub 2014 Sep 21.

Arsenic methylation capacity and obesity are associated with insulin resistance in obese children and adolescents.

Author information

1
School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
2
School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
3
Department of Chinese Medicine, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taoyuan, Taiwan.
4
School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
5
Department of Emergency, Min-Sheng General Hospital, Taoyuan, Taiwan.
6
School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
7
School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: ymhsueh@tmu.edu.tw.

Abstract

The goal of the present study was to compare the arsenic methylation capacities in elementary school and junior high school students in an area of Taiwan with low arsenic exposure, and explore the influence of both arsenic methylation capacity and obesity on insulin resistance in these children and adolescents using the HOMA-IR index. We recruited 303 elementary school students and 319 junior high school students in Taipei City from September 2007 to November 2011. Concentrations of inorganic arsenic (arsenite + arsenate), monomethylarsonic acid (MMA(V)) and dimethylarsinic acid (DMA(V)) were determined by a high-performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Insulin resistance was determined by HOMA-IR. Elementary school students had significantly lower inorganic arsenic percentage and a higher DMA(V) percentage than junior high school students. It seems that the former had better arsenic methylation capability than the latter. The HOMA-IR value was significantly and positively related to the sum of the urinary inorganic and methylated arsenic (TotalAs) concentrations and also the BMI Z score, with the regression coefficients (β) being 0.058 (p < 0.001) and 0.001 (p = 0.027), respectively. The higher BMI values and higher TotalAs concentration were associated with higher HOMA-IR values in children and adolescents in Taiwan.

KEYWORDS:

Adolescents; Arsenic methylation capability; HOMA-IR; Insulin resistance; Obesity

PMID:
25241017
DOI:
10.1016/j.fct.2014.08.018
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center