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Nanomedicine. 2015 Jan;11(1):195-206. doi: 10.1016/j.nano.2014.09.004. Epub 2014 Sep 18.

Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent.

Author information

1
Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
2
Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
3
Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA.
4
Analytical Imaging Facility, Albert Einstein College of Medicine, Bronx, NY, USA.
5
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
6
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA; School of Chemical, Biological and Environmental Engineering, Oregon State University, Corvallis, OR, USA.
7
Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: adfriedm@montefiore.org.

Abstract

Burn wounds are often complicated by bacterial infection, contributing to morbidity and mortality. Agents commonly used to treat burn wound infection are limited by toxicity, incomplete microbial coverage, inadequate penetration, and rising resistance. Curcumin is a naturally derived substance with innate antimicrobial and wound healing properties. Acting by multiple mechanisms, curcumin is less likely than current antibiotics to select for resistant bacteria. Curcumin's poor aqueous solubility and rapid degradation profile hinder usage; nanoparticle encapsulation overcomes this pitfall and enables extended topical delivery of curcumin. In this study, we synthesized and characterized curcumin nanoparticles (curc-np), which inhibited in vitro growth of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa in dose-dependent fashion, and inhibited MRSA growth and enhanced wound healing in an in vivo murine wound model. Curc-np may represent a novel topical antimicrobial and wound healing adjuvant for infected burn wounds and other cutaneous injuries.

KEYWORDS:

Antimicrobial; Burn wound; Curcumin; Infection; Nanoparticle; Wound healing

PMID:
25240595
PMCID:
PMC4461434
DOI:
10.1016/j.nano.2014.09.004
[Indexed for MEDLINE]
Free PMC Article

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