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Am J Clin Pathol. 2014 Oct;142(4):485-91. doi: 10.1309/AJCP4L5CJGKTJVDD.

Nevus-associated melanomas: clinicopathologic features.

Author information

1
From the Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil; danielleshitara@yahoo.com.br.
2
From the Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil;
3
Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain and CIBER de Enfermedades Raras, Instituto de Salud Carlos III, Barcelona, Spainand;
4
From the Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil; Department of Pathology, Federal University of São Paulo, São Paulo, Brazil.

Abstract

OBJECTIVES:

The clinical significance of nevus-associated melanoma compared with de novo melanomas remains controversial. It has been suggested that nevus-associated melanomas have a higher Breslow thickness and therefore worse prognosis. Over a 10-year period, this study evaluated the incidence of nevus-associated melanoma and its prognostic significance related to clinicopathologic features.

METHODS:

Cross-sectional study from 1995 through 2004 in a dermatopathology referral center. With available data, we evaluated sex, primary location, histologic subtype, Breslow thickness, Clark level, presence of ulceration, associated lesion, and histologic subtype of the associated lesion.

RESULTS:

Of 135,653 pathologic records from skin biopsy specimens over a 10-year period, 1,190 melanoma records were selected. Nevus-associated melanomas corresponded to 390 (32.8%) melanomas, with thin melanomas having a nevus 1.52 times the association observed with thick melanomas (>1.01 mm; 95% confidence interval, 1.16-1.99; P < .001). Superficial spreading melanoma was the most frequent, while no lentigo maligna melanoma was associated with nevi. The median Breslow thickness of nevus-associated melanomas was lower than that of de novo melanomas.

CONCLUSIONS:

Nevus-associated melanomas, which represent one-third of the melanomas in southeast Brazil, are associated with intermittent sun exposure, superficial spreading melanomas, and lower Breslow thickness. This is one of the largest series describing nevus-associated melanomas in Latin America.

KEYWORDS:

Breslow; De novo melanoma; Histologic subtype; Nevus-associated melanomas

PMID:
25239415
DOI:
10.1309/AJCP4L5CJGKTJVDD
[Indexed for MEDLINE]

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