Format

Send to

Choose Destination
Cell Calcium. 2014 Nov;56(5):340-61. doi: 10.1016/j.ceca.2014.09.001. Epub 2014 Sep 8.

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.

Author information

1
Pole d'endocrinologie, diabète et nutrition, Institut de recherche expérimentale et clinique, Université Catholique de Louvain, B-1200 Brussels, Belgium. Electronic address: Patrick.gilon@uclouvain.be.
2
Pole d'endocrinologie, diabète et nutrition, Institut de recherche expérimentale et clinique, Université Catholique de Louvain, B-1200 Brussels, Belgium.
3
Section of Cell Biology, Department of Medicine, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital, Du Cane Road, London W13 0NN, United Kingdom.
4
CNRS UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, France; INSERM U661, Institut de Génomique Fonctionnelle, Montpellier, France; Institut de Génomique Fonctionnelle, Universités de Montpellier 1 et 2, Montpellier, France. Electronic address: magalie.ravier@igf.cnrs.fr.

Abstract

Changes in cytosolic free Ca(2+) concentration ([Ca(2+)]c) play a crucial role in the control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is controlled by the finely tuned balance between Ca(2+) influx (mainly through voltage-dependent Ca(2+) channels, but also through voltage-independent Ca(2+) channels like store-operated channels) and efflux pathways. Changes in [Ca(2+)]c directly affect [Ca(2+)] in various organelles including the endoplasmic reticulum (ER), mitochondria, the Golgi apparatus, secretory granules and lysosomes, as imaged using recombinant targeted probes. Because most of these organelles have specific Ca(2+) influx and efflux pathways, they mutually influence free [Ca(2+)] in the others. In this article, we review the mechanisms of control of [Ca(2+)] in various compartments and particularly the cytosol, the endoplasmic reticulum ([Ca(2+)]ER), acidic stores and mitochondrial matrix ([Ca(2+)]mito), focusing chiefly on the most important physiological stimulus of β-cells, glucose. We also briefly review some alterations of β-cell Ca(2+) homeostasis in Type 2 diabetes.

KEYWORDS:

Calcium signaling; Diabetes; β-Cells

PMID:
25239387
DOI:
10.1016/j.ceca.2014.09.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center