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Fertil Steril. 2014 Nov;102(5):1444-1451.e3. doi: 10.1016/j.fertnstert.2014.08.001. Epub 2014 Sep 16.

Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk?

Author information

1
Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands. Electronic address: n.m.p.daan@umcutrecht.nl.
2
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, the Netherlands.
3
Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands.
4
Woman and Baby Division, Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
5
Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, the Netherlands.
6
Department of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, the Netherlands.

Abstract

OBJECTIVE:

To study the cardiometabolic profile characteristics and compare the prevalence of cardiovascular (CV) risk factors between women with different polycystic ovary syndrome (PCOS) phenotypes.

DESIGN:

A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS.

SETTING:

Specialized reproductive outpatient clinic.

PATIENT(S):

Women of reproductive age (18-45 years) diagnosed with PCOS.

INTERVENTION(S):

Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation.

MAIN OUTCOME MEASURE(S):

Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome.

RESULT(S):

Women with hyperandrogenic PCOS (n=1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol‚Č•3.0 mmol/L; 52.2%) were highly prevalent.

CONCLUSION(S):

Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. However, all women with PCOS should be screened for the presence of CV risk factors, since the frequently found derangements at a young age imply an elevated risk for the development of CV disease later in life.

KEYWORDS:

Polycystic ovary syndrome; cardiovascular risk

[Indexed for MEDLINE]

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