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Nutr Hosp. 2014 Sep 1;30(3):467-77. doi: 10.3305/nh.2014.30.3.7632.

[Contribution of omega-3 fatty acids for memory and cognitive function].

[Article in Spanish; Abstract available in Spanish from the publisher]

Author information

1
Departamento de Gastroenterología de la Facultad de Medicina de la Universidad de São Paulo.. dan@ganep.com.br.
2
Laboratorio de Investigación Médica LIM 35 - FMUSP. Brasil.. prigarla@gmail.com.

Abstract

in English, Spanish

INTRODUCTION:

A decline in memory and cognitive function is considered to be a normal consequence of aging. Polyunsaturated omega-3 fatty acids are increasingly proposed as dietary supplements with the ability to reduce the risk of cognitive decline, including Alzheimer's disease (AD).

AIM:

To study the effect of omega-3 on cognitive decline through the review of recent observational, interventional, and experimental studies.

METHODS:

We conducted a Pubmed, Medline, Cochrane and Embase search for epidemiological and clinical studies in the international literature using combinations of the following keywords: "Alzheimer's disease", "mild cognitive impairment", "cognitive function", "dietary factors", "omega-3 fatty acids", "EPA and DHA".

CONCLUSIONS:

Studies have shown the protective role of omega-3 fatty acids in mild cognitive impairment, dementia, and the risk and progression of Alzheimer's disease in the elderly. Further studies are needed to understand the mechanism of action of omega-3 fatty acids on cognition. Doses, composition of EPA and DHA capsules and time of supplementation should be explored.

PMID:
25238820
DOI:
10.3305/nh.2014.30.3.7632
[Indexed for MEDLINE]
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