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J Ren Nutr. 2015 Jan;25(1):50-6. doi: 10.1053/j.jrn.2014.07.009. Epub 2014 Sep 17.

The short-term effects of olive oil and flaxseed oil for the treatment of constipation in hemodialysis patients.

Author information

1
Graduate Program in Nutrition, Federal University of São Paulo, São Paulo, Brazil.
2
Department of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil.
3
Graduate Program in Nutrition, Federal University of São Paulo, São Paulo, Brazil; Department of Medicine, Division of Nephrology, Federal University of São Paulo, São Paulo, Brazil. Electronic address: lcuppari@uol.com.br.

Abstract

OBJECTIVES:

To evaluate the effects of olive oil and flaxseed oil compared with mineral oil for the treatment of constipation in patients undergoing hemodialysis.

METHODS:

A 4-week, double-blind, randomized, and controlled trial was conducted. Fifty constipated patients (29% male, 51 ± 12 years) diagnosed by the Rome III criteria were randomly assigned to receive mineral oil (control group; n = 17), olive oil (n = 16), or flaxseed oil (n = 17). The initial oil dose was 4 mL/day, and adjustments during the follow-up could be made as needed. The impact of the intervention was assessed by the Rome III criteria scores.

RESULTS:

The most frequent symptoms of constipation evaluated by the Roma III criteria at baseline were comparable among the groups and included "incomplete evacuation" (92%), "lumpy or hard stools," (72%) and "anorectal obstruction" (70%). The Rome III score improved significantly in patients receiving mineral oil (10.5 ± 5.0 to 4.1 ± 4.0; P < .01), olive oil (10.3 ± 4.2 to 3.2 ± 3.8; P = .01), and flaxseed oil (9.6 ± 4.2 to 6.0 ± 5.1; P < .01), with no significant group-by-time interaction (P = .15). The scores of 5 from 6 constipation symptoms reduced similarly in the mineral oil and olive oil groups, whereas only the frequency of evacuation and the consistency of stools improved in the flaxseed oil group.

CONCLUSIONS:

We demonstrated that the daily use of olive oil or flaxseed oil was as effective as mineral oil in the treatment of constipation in patients undergoing hemodialysis.

PMID:
25238699
DOI:
10.1053/j.jrn.2014.07.009
[Indexed for MEDLINE]

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