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ACS Appl Mater Interfaces. 2014 Oct 8;6(19):16487-92. doi: 10.1021/am5057163. Epub 2014 Sep 23.

Tailoring Mg(x)Mn(1-x)Fe(2)O(4) superparamagnetic nanoferrites for magnetic fluid hyperthermia applications.

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Biomedical Research Institute, Korea Institute of Science and Technology (KIST) , Seoul 136-791, Republic of Korea.


A superparamagnetic nanoferrite (SPNF) with high magnetic moment, AC magnetically induced heating (AC-heating) capacity, and good biocompatibility is the most vital part of magnetic fluid hyperthermia for utilizing it in the clinics. Herein, we precisely tune magnetic properties and AC-heating characteristics of MgxMn1-xFe2O4 SPNF via chemically controlling the cations' concentration and distribution to develop a tailored MgxMn1-xFe2O4 SPNF as a potential magnetic fluid hyperthermia agent. The magnetic and AC-heating characteristics of the tailored MgxMn1-xFe2O4 SPNF are strongly dependent on the Mg/Mn cations' concentration and distribution, and Mg0.285Mn0.715Fe2O4 SPNF exhibits the highest saturation magnetization and AC-heating capacity as well as high biocompatibility.


MgMnFe2O4; magnetic hyperthermia; nanoferrite; nanofluid; superparamagnetic particle

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