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Immunity. 2014 Sep 18;41(3):366-374. doi: 10.1016/j.immuni.2014.09.006.

Innate lymphoid cells in inflammation and immunity.

Author information

1
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. Electronic address: anm@mrc-lmb.cam.ac.uk.
2
Academic Medical Center, University of Amsterdam, Department of Cell Biology & Histology, 1105BK Amsterdam, the Netherlands.
3
Institut Pasteur, Lymphoid Tissue Development Unit, Paris 75724, France.

Abstract

Innate lymphoid cells (ILCs) were first described as playing important roles in the development of lymphoid tissues and more recently in the initiation of inflammation at barrier surfaces in response to infection or tissue damage. It has now become apparent that ILCs play more complex roles throughout the duration of immune responses, participating in the transition from innate to adaptive immunity and contributing to chronic inflammation. The proximity of ILCs to epithelial surfaces and their constitutive strategic positioning in other tissues throughout the body ensures that, in spite of their rarity, ILCs are able to regulate immune homeostasis effectively. Dysregulation of ILC function might result in chronic pathologies such as allergies, autoimmunity, and inflammation. A new role for ILCs in the maintenance of metabolic homeostasis has started to emerge, underlining their importance in fundamental physiological processes beyond infection and immunity.

PMID:
25238094
DOI:
10.1016/j.immuni.2014.09.006
[Indexed for MEDLINE]
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