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Immunity. 2014 Sep 18;41(3):341-342. doi: 10.1016/j.immuni.2014.08.016.

Can the suppressive activity of myeloid-derived suppressor cells be "chop"ped?

Author information

1
The Wistar Institute, Philadelphia, PA 19104, USA.
2
The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: dgabrilovich@wistar.org.

Abstract

Myeloid-derived suppressor cells (MDSCs) are one of the major negative regulators of immune responses. In this issue of Immunity, Thevenot et al. (2014) showed that in tumors, the suppressive activity of MDSCs is regulated by transcription factor Chop.

PMID:
25238087
DOI:
10.1016/j.immuni.2014.08.016
[Indexed for MEDLINE]
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