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Molecules. 2014 Sep 18;19(9):14919-47. doi: 10.3390/molecules190914919.

Experimental studies of the molecular pathways regulated by exercise and resveratrol in heart, skeletal muscle and the vasculature.

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Department of Pharmacology & Therapeutics and the Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Research Theme of the Manitoba Institute of Child Health, University of Manitoba, 601 John Buhler Research Centre, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada.
Department of Pediatrics and the Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, 458 Heritage Medical Research Centre, Edmonton, AB T6G 2S2, Canada.


Regular exercise contributes to healthy aging and the prevention of chronic disease. Recent research has focused on the development of molecules, such as resveratrol, that activate similar metabolic and stress response pathways as exercise training. In this review, we describe the effects of exercise training and resveratrol on some of the organs and tissues that act in concert to transport oxygen throughout the body. In particular, we focus on animal studies that investigate the molecular signaling pathways induced by these interventions. We also compare and contrast the effects of exercise and resveratrol in diseased states.

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