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Exp Dermatol. 2014 Oct;23 Suppl 1:18-22. doi: 10.1111/exd.12394.

Orange peel extract, containing high levels of polymethoxyflavonoid, suppressed UVB-induced COX-2 expression and PGE2 production in HaCaT cells through PPAR-γ activation.

Author information

1
Advanced Technology Research Laboratory, NOF Corporation, Japan.

Abstract

Ultraviolet light (UV) induces an inflammatory response in the skin by cyclooxygenase (COX)-2 expression and prostaglandin (PG) E2 production. Citrus peel has been used as a natural medicine. It contains polymethoxyflavonoids (PMFs) as a major ingredient, which have anti-inflammatory activity. We obtained orange peel extract containing high levels of PMFs. The extract suppressed UVB-induced COX-2 expression and PGE2 production in HaCaT cells. Furthermore, it was found that this extract acted as a peroxisome proliferator-activated receptor (PPAR)-γ agonist. The suppression of UVB-induced COX-2 expression by this extract was inhibited by GW 9662 and T0070907, which are both PPAR-γ antagonists. It is therefore suggested that orange peel extract, containing high levels of PMFs, suppresses UVB-induced COX-2 expression and PGE2 production through PPAR-γ. Hence, these extracts could provide useful protection against or alleviation of UV damage.

KEYWORDS:

cyclooxygenase-2; orange peel; polymethoxyflavonoid; proliferator-activated receptor-γ; ultraviolet light

PMID:
25234831
DOI:
10.1111/exd.12394
[Indexed for MEDLINE]

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