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Nat Rev Neurosci. 2014 Oct;15(10):637-54. doi: 10.1038/nrn3819.

Cation-chloride cotransporters in neuronal development, plasticity and disease.

Author information

1
1] Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland. [2] Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland.
2
University of Texas at Dallas, School of Behavior and Brain Sciences, Dallas, Texas 75093, USA.
3
Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California 95616, USA.
4
Department of Biosciences, University of Helsinki, 00014 Helsinki, Finland.

Abstract

Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades, research on ion transporters is in its infancy. In recent years, it has become evident that one family of ion transporters, cation-chloride cotransporters (CCCs), and in particular K(+)-Cl(-) cotransporter 2 (KCC2), have seminal roles in shaping GABAergic signalling and neuronal connectivity. Studying the functions of these transporters may lead to major paradigm shifts in our understanding of the mechanisms underlying brain development and plasticity in health and disease.

PMID:
25234263
PMCID:
PMC4294553
DOI:
10.1038/nrn3819
[Indexed for MEDLINE]
Free PMC Article
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