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Nat Rev Immunol. 2014 Oct;14(10):653-66. doi: 10.1038/nri3737. Epub 2014 Sep 19.

Siglec-mediated regulation of immune cell function in disease.

Author information

1
Departments of Cell and Molecular Biology, Immunology and Microbial Science, and Physiological Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
2
Division of Cell Signalling and Immunology, Wellcome Trust Building, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Abstract

All mammalian cells display a diverse array of glycan structures that differ from those that are found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin-like receptors that participate in the discrimination between self and non-self, and that regulate the function of cells in the innate and adaptive immune systems through the recognition of their glycan ligands. In this Review, we describe the recent advances in our understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer.

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PMID:
25234143
PMCID:
PMC4191907
DOI:
10.1038/nri3737
[Indexed for MEDLINE]
Free PMC Article

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