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Neuron. 2014 Sep 17;83(6):1284-302. doi: 10.1016/j.neuron.2014.08.041.

Toward a genetic dissection of cortical circuits in the mouse.

Author information

1
Cold Spring Harbor Laboratory, New York, NY 11724, USA. Electronic address: huangj@cshl.edu.

Abstract

The mammalian neocortex gives rise to a wide range of mental activities and consists of a constellation of interconnected areas that are built from a set of basic circuit templates. Major obstacles to understanding cortical architecture include the diversity of cell types, their highly recurrent local and global connectivity, dynamic circuit operations, and a convoluted developmental assembly process rooted in the genome. With our increasing knowledge of gene expression and developmental genetic principles, it is now feasible to launch a program of genetic dissection of cortical circuits through systematic targeting of cell types and fate mapping of neural progenitors. Strategic design of even a modest number of mouse driver lines will facilitate efforts to compile a cell type parts list, build a Cortical Cell Atlas, establish experimental access to modern tools, integrate studies across levels, and provide coordinates for tracing developmental trajectory from circuit assembly to functional operation.

PMID:
25233312
PMCID:
PMC4169123
DOI:
10.1016/j.neuron.2014.08.041
[Indexed for MEDLINE]
Free PMC Article

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