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Nat Immunol. 2014 Oct;15(10):895-9. doi: 10.1038/ni.2961.

Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges.

Author information

1
Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Denmark; and Research Centre for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
2
Division of Infectious Disease, Department of Pediatrics, University of British Columbia, Child &Family Research Institute, Vancouver, Canada.

Abstract

Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.

PMID:
25232810
DOI:
10.1038/ni.2961
[Indexed for MEDLINE]

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