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World J Clin Cases. 2014 Sep 16;2(9):478-81. doi: 10.12998/wjcc.v2.i9478.

Splenic lymphoma with massive splenomegaly: Case report with review of literature.

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Sachin B Ingle, Department of Pathology, MIMSR Medical College, Latur, Maharashtra 4132512, India.


As per strict criteria of Das Gupta et al, primary splenic lymphoma is very rare. Herein, we are reporting an unusual case of primary large cell splenic lymphoma of B lineage in a middle aged female presenting with massive splenomegaly (3.8 kg) and hypersplenism. After performing therapeutic splenectomy for hypersplenism, a precise diagnosis of diffuse large B cell lymphoma was made on histopathology and confirmed by immunohistochemistry. The patient responded well to standard (Cyclophosphamide, Hydroxydaunorubicin, Oncovin (vincristine), Prednisone or prednisolone) regimen last year and is now in full remission. The splenectomy thereby has prevented the potential grave complications related to hypersplenism and splenic rupture. Our aim behind highlighting the topic is to specify that emergency splenectomy followed by anticoagulation therapy is an effective plan of management to prevent untoward complications related to disease and treatment.


Anticoagulation; Huge splenic lymphoma; Pancytopenia; Splenectomy

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