Send to

Choose Destination
World J Hepatol. 2014 Aug 27;6(8):613-20. doi: 10.4254/wjh.v6.i8.613.

Circulating microRNAs in patients with non-alcoholic fatty liver disease.

Author information

Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.



To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease (NAFLD).


Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The relative expressions of miR-197, miR-146b, miR-10b, miR-181d, miR-34a, miR-122, miR-99a and miR-29a were analyzed using real-time polymerase chain reaction.


Serum levels of miR-181d, miR-99a, miR-197 and miR-146b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR-99a were inversely correlated with serum gamma glutamyl transferase levels in non-alcoholic steatohepatitis patients.


NAFLD is associated with altered serum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD.


MicroRNA; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Noninvasive; Serum markers

Supplemental Content

Full text links

Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
Loading ...
Support Center