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World J Hepatol. 2014 Aug 27;6(8):613-20. doi: 10.4254/wjh.v6.i8.613.

Circulating microRNAs in patients with non-alcoholic fatty liver disease.

Author information

1
Mehmet Celikbilek, Mevlut Baskol, Serkan Dogan, Sebnem Gursoy, Kadri Guven, Omer Ozbakır, Mehmet Yucesoy, Department of Gastroenterology, Erciyes University, Medical School, 38039 Kayseri, Turkey.

Abstract

AIM:

To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease (NAFLD).

METHODS:

Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The relative expressions of miR-197, miR-146b, miR-10b, miR-181d, miR-34a, miR-122, miR-99a and miR-29a were analyzed using real-time polymerase chain reaction.

RESULTS:

Serum levels of miR-181d, miR-99a, miR-197 and miR-146b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum levels of miR-197 and miR-10b were inversely correlated with degree of inflammation and miR-181d and miR-99a were inversely correlated with serum gamma glutamyl transferase levels in non-alcoholic steatohepatitis patients.

CONCLUSION:

NAFLD is associated with altered serum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD.

KEYWORDS:

MicroRNA; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Noninvasive; Serum markers

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