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Nucleic Acids Res. 2015 Jan;43(Database issue):D873-8. doi: 10.1093/nar/gku843. Epub 2014 Sep 17.

The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource.

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Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
University of North Carolina at Chapel Hill, NC, USA.
Skolkovo Institute of Science and Technology, Moscow region, Russia.
Institute of Biology of Komi Science Center of RAS, Syktyvkar, Russia Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
Department of Biological Sciences, Wayne State University, Detroit, MI, USA.
Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK


Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, in order to obtain age-related data at various levels. To address this and facilitate integrative, system-level studies of ageing we developed the Digital Ageing Atlas (DAA). The DAA is a one-stop collection of human age-related data covering different biological levels (molecular, cellular, physiological, psychological and pathological) that is freely available online ( Each of the >3000 age-related changes is associated with a specific tissue and has its own page displaying a variety of information, including at least one reference. Age-related changes can also be linked to each other in hierarchical trees to represent different types of relationships. In addition, we developed an intuitive and user-friendly interface that allows searching, browsing and retrieving information in an integrated and interactive fashion. Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes.

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