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Nucleic Acids Res. 2015 Jan;43(Database issue):D873-8. doi: 10.1093/nar/gku843. Epub 2014 Sep 17.

The Digital Ageing Atlas: integrating the diversity of age-related changes into a unified resource.

Author information

1
Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
2
University of North Carolina at Chapel Hill, NC, USA.
3
Skolkovo Institute of Science and Technology, Moscow region, Russia.
4
Institute of Biology of Komi Science Center of RAS, Syktyvkar, Russia Moscow Institute of Physics and Technology, Dolgoprudny, Russia.
5
Department of Biological Sciences, Wayne State University, Detroit, MI, USA.
6
Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool, UK jp@senescence.info.

Abstract

Multiple studies characterizing the human ageing phenotype have been conducted for decades. However, there is no centralized resource in which data on multiple age-related changes are collated. Currently, researchers must consult several sources, including primary publications, in order to obtain age-related data at various levels. To address this and facilitate integrative, system-level studies of ageing we developed the Digital Ageing Atlas (DAA). The DAA is a one-stop collection of human age-related data covering different biological levels (molecular, cellular, physiological, psychological and pathological) that is freely available online (http://ageing-map.org/). Each of the >3000 age-related changes is associated with a specific tissue and has its own page displaying a variety of information, including at least one reference. Age-related changes can also be linked to each other in hierarchical trees to represent different types of relationships. In addition, we developed an intuitive and user-friendly interface that allows searching, browsing and retrieving information in an integrated and interactive fashion. Overall, the DAA offers a new approach to systemizing ageing resources, providing a manually-curated and readily accessible source of age-related changes.

PMID:
25232097
PMCID:
PMC4384002
DOI:
10.1093/nar/gku843
[Indexed for MEDLINE]
Free PMC Article

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