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Biosci Biotechnol Biochem. 2014;78(7):1212-20. doi: 10.1080/09168451.2014.915728. Epub 2014 May 28.

Collagen peptide and vitamin C additively attenuate age-related skin atrophy in Sod1-deficient mice.

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a Department of Advanced Aging Medicine , Chiba University Graduate School of Medicine , Chiba , Japan.


Age-related skin thinning is correlated with a decrease in the content of collagen in the skin. Accumulating evidence suggests that collagen peptide (CP) and vitamin C (VC) transcriptionally upregulate type I collagen in vivo. However, the additive effects of CP and VC on age-related skin changes remain unclear. We herein demonstrate that CP and a VC derivative additively corrected age-related skin thinning via reduced oxidative damage in superoxide dismutase 1 (Sod1)-deficient mice. Co-treatment with these compounds significantly normalized the altered gene expression of Col1a1, Has2, and Ci1, a proton-coupled oligopeptide transporter, in Sod1(-/-) skin. The in vitro analyses further revealed that collagen oligopeptide, a digestive product of ingested CP, significantly promoted the bioactivity of the VC derivative with respect to the migration and proliferation of Sod1(-/-) fibroblasts. These findings suggest that combined treatment with CP and VC is effective in cases of age-related skin pathology.


collagen peptide; proton-coupled oligopeptide transporter; skin atrophy; superoxide dismutase; vitamin C

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