Format

Send to

Choose Destination
Cephalalgia. 2015 Jun;35(7):627-30. doi: 10.1177/0333102414550108. Epub 2014 Sep 16.

Understanding migraine using dynamic network biomarkers.

Author information

1
Department of Physics, Nonlinear Dynamics, Cardiovascular Physics, Humboldt-Universität zu Berlin, Germany dahlem@physik.hu-berlin.de.
2
Department of Physics, Nonlinear Dynamics, Cardiovascular Physics, Humboldt-Universität zu Berlin, Germany Potsdam Institute for Climate Impact Research, Germany Institute for Complex Systems and Mathematical Biology, University of Aberdeen, UK.
3
Department of Neurology, Leiden University Medical Centre, the Netherlands.
4
Collaborative Research Center for Innovative Mathematical Modelling, Institute of Industrial Science, University of Tokyo, Japan.
5
Department of Aquatic Ecology & Water Quality Management, Wageningen University, the Netherlands.
6
Center for Experimental Medicine, Department of Systems Neuroscience, Universitätsklinikum Hamburg-Eppendorf, Germany.

Abstract

BACKGROUND:

Mathematical modeling approaches are becoming ever more established in clinical neuroscience. They provide insight that is key to understanding complex interactions of network phenomena, in general, and interactions within the migraine-generator network, in particular.

PURPOSE:

In this study, two recent modeling studies on migraine are set in the context of premonitory symptoms that are easy to confuse for trigger factors. This causality confusion is explained, if migraine attacks are initiated by a transition caused by a tipping point.

CONCLUSION:

We need to characterize the involved neuronal and autonomic subnetworks and their connections during all parts of the migraine cycle if we are ever to understand migraine. We predict that mathematical models have the potential to dismantle large and correlated fluctuations in such subnetworks as a dynamic network biomarker of migraine.

KEYWORDS:

Migraine; premonitory symptoms; tipping point; triggers

PMID:
25228683
DOI:
10.1177/0333102414550108
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center