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Public Health Genomics. 2014;17(5-6):265-71. doi: 10.1159/000365895. Epub 2014 Sep 9.

DruGeVar: an online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics.

Author information

1
Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.

Abstract

BACKGROUND/AIMS:

Pharmacogenomics aims to rationalize drug use by minimizing drug toxicity and/or by increasing drug efficacy. A large number of genomic markers have been correlated with variable drug responses and severity of adverse drug reactions. Although a number of these drugs bear pharmacogenomic information in their labels--approved by regulatory agencies--and comprehensive drug/gene lists exist online, information related to the respective pharmacogenomic biomarkers is currently missing from such lists.

METHODS:

We extracted information from the published literature and online resources and developed DruGeVar (http://drugevar.genomicmedicinealliance.org), an online resource triangulating drugs with genes and pharmacogenomic biomarkers in an effort to build a comprehensive database that could serve clinical pharmacogenomics.

RESULTS AND CONCLUSIONS:

A user-friendly data querying and visualization interface allows users to formulate simple and complex queries. Such a database would be readily applicable as a stand-alone resource or a plug-in module for other databases.

PMID:
25228099
DOI:
10.1159/000365895
[Indexed for MEDLINE]

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