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Dement Geriatr Cogn Disord. 2015;39(1-2):1-11. doi: 10.1159/000366040. Epub 2014 Sep 11.

The Mini-Addenbrooke's Cognitive Examination: a new assessment tool for dementia.

Author information

1
Brain and Mind Research Institute, University of New South Wales, Sydney, N.S.W., Australia.

Abstract

BACKGROUND/AIMS:

We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. Comparisons were also made with the Mini Mental State Examination (MMSE).

METHOD:

The M-ACE was developed using Mokken scaling analysis in 117 dementia patients [behavioural variant frontotemporal dementia (bvFTD), n = 25; primary progressive aphasia (PPA), n = 49; Alzheimer's disease (AD), n = 34; corticobasal syndrome (CBS), n = 9] and validated in an independent sample of 164 dementia patients (bvFTD, n = 23; PPA, n = 82; AD, n = 38; CBS, n = 21) and 78 controls, who also completed the MMSE.

RESULTS:

The M-ACE consists of 5 items with a maximum score of 30. Two cut-offs were identified: (1) ≤25/30 has both high sensitivity and specificity, and (2) ≤21/30 is almost certainly a score to have come from a dementia patient regardless of the clinical setting. The M-ACE is more sensitive than the MMSE and is less likely to have ceiling effects.

CONCLUSION:

The M-ACE is a brief and sensitive cognitive screening tool for dementia. Two cut-offs (25 or 21) are recommended.

PMID:
25227877
PMCID:
PMC4774042
DOI:
10.1159/000366040
[Indexed for MEDLINE]
Free PMC Article

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