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Biomed Mater Eng. 2014;24(6):2025-39. doi: 10.3233/BME-141012.

Effect of balanced low pressure drying of curcuma longa leaf on skin immune activation activities.

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Department of Medical Biomaterials Engineering, Kangwon National University, Chuncheon 200-701, Republic of Korea.
Shebah Biotech Co., Chuncheon Bioindustry Foundation Hi-Tech Venture Town, Chuncheon 200-161, Korea.
Department of Food Science and Engineering, Seowon University, Cheongju 361-742, Republic of Korea.


The effect of balanced low pressure drying pretreatment associated with ultrasonication extraction (BU) on the enhancement of skin immune modulatory activities of Curcuma longa leaf was studied by comparing with conventional hot air drying (HE), freeze drying (FE) and balanced low pressure drying (BE) pretreatment processes. In considering skin immune activation activities such as the inhibition of hyaluronidase activity, the BU extract showed ca. 10% higher than those of HE, and even higher than that of the FE extract. Nitric oxide production from macrophage of the BU extract in adding 1.0 mg/mL was increased up to 16.5 μM. When measuring inhibition of IL-6 and TNF-a production from the human T lymphocytes (T cell), the BU extract also showed 53% and 78% of inhibition effect, respectively. It is found that the BU extract could effectively suppress the expression levels of skin inflammation related genes such as Cox-2 and iNOS, down to 80% and 85% compared to the control, respectively. Balanced low pressure drying process was especially active on dehydration of the leaves with minimizing the destruction and making easier elution of the bioactive substances, which resulted in higher extraction yield and better biological activities.


Curcuma longa; balanced drying process; skin immune activation activities; ultrasonication extraction process

[Indexed for MEDLINE]

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