Monocyte activation, but not microbial translocation, is independently associated with markers of endovascular dysfunction in HIV-infected patients receiving cART

J Acquir Immune Defic Syndr. 2014 Dec 1;67(4):370-4. doi: 10.1097/QAI.0000000000000339.

Abstract

Background: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.

Methods: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.

Results: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.

Conclusions: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active
  • Arginine / analogs & derivatives
  • Arginine / blood
  • Bacterial Translocation*
  • Biomarkers / blood
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology*
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis
  • HIV Infections / blood
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • Humans
  • Lipopolysaccharide Receptors / blood
  • Lipopolysaccharides / blood
  • Male
  • Middle Aged
  • Monocytes / physiology*

Substances

  • Anti-HIV Agents
  • Biomarkers
  • Fibrin Fibrinogen Degradation Products
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides
  • fibrin fragment D
  • symmetric dimethylarginine
  • N,N-dimethylarginine
  • Arginine