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Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14193-8. doi: 10.1073/pnas.1413970111. Epub 2014 Sep 15.

Mathematical model of renal interstitial fibrosis.

Author information

1
Mathematical Biosciences Institute.
2
Division of Nephrology, College of Medicine, and.
3
Mathematical Biosciences Institute and Department of Mathematics, The Ohio State University, Columbus, OH 43210 afriedman@mbi.osu.edu.

Abstract

Lupus nephritis (LN) is an autoimmune disease that occurs when autoantibodies complex with self-antigen and form immune complexes that accumulate in the glomeruli. These immune complexes initiate an inflammatory response resulting in glomerular injury. LN often concomitantly affects the tubulointerstitial compartment of the kidney, leading first to interstitial inflammation and subsequently to interstitial fibrosis and atrophy of the renal tubules if not appropriately treated. Presently the only way to assess interstitial inflammation and fibrosis is through kidney biopsy, which is invasive and cannot be repeated frequently. Hence, monitoring of disease progression and response to therapy is suboptimal. In this paper we describe a mathematical model of the progress from tubulointerstitial inflammation to fibrosis. We demonstrate how the model can be used to monitor treatments for interstitial fibrosis in LN with drugs currently being developed or used for nonrenal fibrosis.

KEYWORDS:

math modeling; renal fibrosis; tubulointerstitial inflammation

PMID:
25225370
PMCID:
PMC4191765
DOI:
10.1073/pnas.1413970111
[Indexed for MEDLINE]
Free PMC Article

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