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Adv Nutr. 2014 Sep 15;5(5):624S-633S. doi: 10.3945/an.114.005835. Print 2014 Sep.

Modulation of the gut microbiota by nutrients with prebiotic and probiotic properties.

Author information

1
Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium.
2
Université catholique de Louvain, Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Brussels, Belgium nathalie.delzenne@uclouvain.be.

Abstract

Experimental data in animals, but also observational studies in humans, suggest that the composition of the gut microbiota differs in obese vs. lean individuals, in patients with vs. without diabetes, or in patients presenting other diseases associated with obesity or nutritional disbalance, such as non-alcoholic fatty liver disease (NAFLD) or cardiovascular diseases. In this review, we describe how changes in the composition and/or activity of the gut microbiota by administration of nutrients with probiotic or prebiotic properties can modulate host gene expression and metabolism and thereby positively influence host adipose tissue development and related metabolic disorders.

PMID:
25225347
PMCID:
PMC4188246
DOI:
10.3945/an.114.005835
[Indexed for MEDLINE]
Free PMC Article

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