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J Cell Biol. 2014 Sep 15;206(6):695-706. doi: 10.1083/jcb.201405027.

Systems cell biology.

Author information

1
Seattle Biomedical Research Institute, Seattle, WA 98109 Institute for Systems Biology, Seattle, WA 98109.
2
Seattle Biomedical Research Institute, Seattle, WA 98109 Institute for Systems Biology, Seattle, WA 98109 john.aitchison@seattlebiomed.org.

Abstract

Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling to understand many critical processes that contribute to cellular organization and dynamics. Recently, there have been several advances in technology and in the application of modeling approaches that enable the exploration of the dynamic properties of cells. Merging technology and computation offers an opportunity to objectively address unsolved cellular mechanisms, and has revealed emergent properties and helped to gain a more comprehensive and fundamental understanding of cell biology.

PMID:
25225336
PMCID:
PMC4164942
DOI:
10.1083/jcb.201405027
[Indexed for MEDLINE]
Free PMC Article

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