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J Card Fail. 2014 Dec;20(12):984-95. doi: 10.1016/j.cardfail.2014.09.001. Epub 2014 Sep 16.

Murine models of diastolic dysfunction and heart failure with preserved ejection fraction.

Author information

1
School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland; Noninvasive Cardiovascular Imaging, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: sjhorgan@partners.org.
2
School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland.

Abstract

Left ventricular diastolic dysfunction leads to heart failure with preserved ejection fraction, an increasingly prevalent condition largely driven by modern day lifestyle risk factors. As heart failure with preserved ejection fraction accounts for almost one-half of all patients with heart failure, appropriate nonhuman animal models are required to improve our understanding of the pathophysiology of this syndrome and to provide a platform for preclinical investigation of potential therapies. Hypertension, obesity, and diabetes are major risk factors for diastolic dysfunction and heart failure with preserved ejection fraction. This review focuses on murine models reflecting this disease continuum driven by the aforementioned common risk factors. We describe various models of diastolic dysfunction and highlight models of heart failure with preserved ejection fraction reported in the literature. Strengths and weaknesses of the different models are discussed to provide an aid to translational scientists when selecting an appropriate model. We also bring attention to the fact that heart failure with preserved ejection fraction is difficult to diagnose in animal models and that, therefore, there is a paucity of well described animal models of this increasingly important condition.

KEYWORDS:

Animal models; diabetes and obesity; diastolic dysfunction; heart failure with preserved ejection fraction (HFpEF); hypertension

PMID:
25225111
DOI:
10.1016/j.cardfail.2014.09.001
[Indexed for MEDLINE]
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