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Head Neck. 2016 Jan;38(1):140-6. doi: 10.1002/hed.23861. Epub 2015 May 22.

Prognostic value of level IV metastases from head and neck squamous cell carcinoma.

Author information

1
Department of Otolaryngology, Head and Neck Surgery, Philipp University, Marburg, Germany.
2
Institute of Medical Biometry and Epidemiology, Philipp University, Marburg, Germany.
3
University of Udine School of Medicine, Udine, Italy.

Abstract

BACKGROUND:

The purpose of this study was to evaluate the prognostic value of level IV metastases in head and neck squamous cell carcinoma (HNSCC).

METHODS:

The clinical and histopathological data of 111 patients with HNSCC with pN+ neck who underwent a primary tumor resection with unilateral or bilateral neck dissection were analyzed.

RESULTS:

Level IV metastases were histopathologically proven in 33 patients (29.7%). Pulmonary metastases were observed in 12 of 33 patients (36.4%) with level IV metastases, and in 13 of 78 patients (16.7%) without level IV metastases (p = .04). Multivariate analyzes revealed a significant association between level IV metastases and pulmonary metastases (p = .038). However, an influence on overall (p = .65) or disease-free survival (p = .66) was not observed.

CONCLUSION:

Level IV metastases seem to be a predictive factor for pulmonary metastases but not for overall and disease-free survival in patients with HNSCC.

KEYWORDS:

head and neck cancer; level IV; lymph node metastases; prognosis; pulmonary metastases

PMID:
25224439
DOI:
10.1002/hed.23861
[Indexed for MEDLINE]

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