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Genome Biol. 2014 Aug 27;15(8):453. doi: 10.1186/s13059-014-0453-8.

Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine.

Abstract

The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.

PMID:
25222836
PMCID:
PMC4281956
DOI:
10.1186/s13059-014-0453-8
[Indexed for MEDLINE]
Free PMC Article

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