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Front Endocrinol (Lausanne). 2014 Aug 27;5:140. doi: 10.3389/fendo.2014.00140. eCollection 2014.

The effect of liraglutide on weight loss in women with polycystic ovary syndrome: an observational study.

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1
Copenhagen Fertility Center , Copenhagen , Denmark.

Abstract

OBJECTIVE:

The aim of the present study was to evaluate the effect of the glucagon-like peptide-1 analog liraglutide on weight loss in overweight and obese women with polycystic ovary syndrome (PCOS).

METHODS:

In an observational study, 84 overweight or obese women with PCOS were treated with liraglutide. Baseline characteristics and weight changes at clinical follow-up were recorded. Main outcome measures were absolute and relative weight loss.

RESULTS:

In overweight or obese women with PCOS treated with liraglutide for a minimum of 4 weeks, a mean weight loss of 9.0 kg (95% CI: 7.8-10.1, p < 0.0001) and a mean decrease in BMI of 3.2 kg/m(2) (95% CI: 2.8-3.6, p < 0.0001) were found. A weight loss of more than 5 and 10% of baseline weight was seen in 81.7 and 32.9% of patients, respectively. The mean duration of treatment with liraglutide was 27.8 weeks (SD 19.2).

CONCLUSION:

Treatment with liraglutide in combination with metformin and lifestyle intervention resulted in a significant weight loss in overweight and obese women with PCOS, indicating that liraglutide may be an effective alternative for weight loss in this group of patients. However, larger placebo-controlled studies are needed to confirm this.

KEYWORDS:

GLP-1 analogs; liraglutide; obesity; polycystic ovary syndrome; weight loss

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