Format

Send to

Choose Destination
Trends Immunol. 2014 Nov;35(11):538-48. doi: 10.1016/j.it.2014.08.002. Epub 2014 Sep 11.

Host-microbe interactions shaping the gastrointestinal environment.

Author information

1
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
2
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA. Electronic address: stappenb@pathology.wustl.edu.

Abstract

Tremendous advances have been made in mapping the complexity of the human gut microbiota in both health and disease states. These analyses have revealed that, rather than a constellation of individual species, a healthy microbiota comprises an interdependent network of microbes. The microbial and host interactions that shape both this network and the gastrointestinal environment are areas of intense investigation. Here we review emerging concepts of how microbial metabolic processes control commensal composition, invading pathogens, immune activation, and intestinal barrier function. We posit that all of these factors are critical for the maintenance of homeostasis and avoidance of overt inflammatory disease. A greater understanding of the underlying mechanisms will shed light on the pathogenesis of many diseases and guide new therapeutic interventions.

KEYWORDS:

epithelial barrier; host–microbial interaction; intestinal pathogen; metabolism

PMID:
25220948
PMCID:
PMC4253298
DOI:
10.1016/j.it.2014.08.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center