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Adv Drug Deliv Rev. 2015 Jan;81:169-83. doi: 10.1016/j.addr.2014.09.003. Epub 2014 Sep 16.

Target-responsive DNA/RNA nanomaterials for microRNA sensing and inhibition: the jack-of-all-trades in cancer nanotheranostics?

Author information

1
Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449 Cambridge, MA, USA. Electronic address: jdconde@mit.edu.
2
Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449 Cambridge, MA, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
3
Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449 Cambridge, MA, USA; Department of Anaesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

microRNAs (miRNAs) show high potential for cancer treatment, however one of the most significant bottlenecks in enabling miRNA effect is the need for an efficient vehicle capable of selective targeting to tumor cells without disrupting normal cells. Even more challenging is the ability to detect and silence multiple targets simultaneously with high sensitivity while precluding resistance to the therapeutic agents. Focusing on the pervasive role of miRNAs, herein we review the multiple nanomaterial-based systems that encapsulate DNA/RNA for miRNA sensing and inhibition in cancer therapy. Understanding the potential of miRNA detection and silencing while overcoming existing limitations will be critical to the optimization and clinical utilization of this technology.

KEYWORDS:

Biosensors; Cancer; Nanomaterials; Nanotheranostics; RNAi; Surface modification; Translational medicine; microRNA

PMID:
25220355
DOI:
10.1016/j.addr.2014.09.003
[Indexed for MEDLINE]

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