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Int J Obes (Lond). 2014 Sep;38 Suppl 2:S32-8. doi: 10.1038/ijo.2014.133.

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort.

Author information

1
Department of Paediatrics, University of Pécs, Pécs, Hungary.
2
Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
3
1] Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany [2] Institute of Statistics, Faculty of Mathematics and Computer Science, Bremen University, Bremen, Germany.
4
Epidemiology and Population Genetics, Institute of Food Science, National Research Council, Avellino, Italy.
5
Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia.
6
Research and Education Institute of Child Health, Strovolos, Cyprus.
7
Department of Public Health, University of Ghent, Ghent, Belgium.
8
Department of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden.
9
Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza, Zaragoza, Spain.

Abstract

OBJECTIVE:

To establish age- and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children.

SUBJECTS AND METHODS:

Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary- and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n=539) in our analysis. Using the General Additive Model for Location Scale and Shape, age- and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n=1015) and the whole study sample (n=1338).

RESULTS:

There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from -2.2 to 4.6 μg ml(-1) and from 2.2 to 4.8 ng ml(-1) for adiponectin and leptin, respectively.

CONCLUSIONS:

According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.

PMID:
25219410
DOI:
10.1038/ijo.2014.133
[Indexed for MEDLINE]

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