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Nature. 1989 Mar 2;338(6210):39-44.

Transcription activation by the adenovirus E1a protein.

Author information

1
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

Abstract

The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.

PMID:
2521923
DOI:
10.1038/338039a0
[Indexed for MEDLINE]

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