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Semin Nephrol. 2014 Jul;34(4):384-93. doi: 10.1016/j.semnephrol.2014.06.005. Epub 2014 Jun 13.

Bioengineering kidneys for transplantation.

Author information

1
Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard Stem Cell Institute, Boston, MA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.
2
Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard Stem Cell Institute, Boston, MA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA. Electronic address: hott@mgh.harvard.edu.

Abstract

One in 10 Americans suffers from chronic kidney disease, and close to 90,000 people die each year from causes related to kidney failure. Patients with end-stage renal disease are faced with two options: hemodialysis or transplantation. Unfortunately, the transplantation option is limited because of the shortage of donor organs and the need for immunosuppression. Bioengineered kidney grafts theoretically present a novel solution to both problems. Herein, we discuss the history of bioengineering organs, the current status of bioengineered kidneys, considerations for the future of the field, and challenges to clinical translation. We hope that by integrating principles of tissue engineering, and stem cell and developmental biology, bioengineered kidney grafts will advance the field of regenerative medicine while meeting a critical clinical need.

KEYWORDS:

Kidney; bioengineering; organ engineering; perfusion decellularization; transplantation

PMID:
25217267
PMCID:
PMC4373354
DOI:
10.1016/j.semnephrol.2014.06.005
[Indexed for MEDLINE]
Free PMC Article

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