Format

Send to

Choose Destination
Genetics. 2014 Nov;198(3):995-1000. doi: 10.1534/genetics.114.170241. Epub 2014 Sep 11.

Differential regulation of germline apoptosis in response to meiotic checkpoint activation.

Author information

1
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060.
2
Center for Integrated Protein Science, Department of Biology II, Ludwig Maximilians University, 82152 Munich, Germany.
3
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95060 nbhalla@ucsc.edu.

Abstract

In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.

KEYWORDS:

DNA damage; apoptosis; checkpoint; recombination; synapsis

PMID:
25217053
PMCID:
PMC4224185
DOI:
10.1534/genetics.114.170241
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center