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Curr Opin Immunol. 2014 Dec;31:24-30. doi: 10.1016/j.coi.2014.08.005. Epub 2014 Sep 15.

Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.

Author information

1
Centre for Immune Regulation, Department of Immunology, University of Oslo and Oslo University Hospital - Rikshospitalet, 0372 Oslo, Norway. Electronic address: l.m.sollid@medisin.uio.no.
2
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
3
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: kai_wucherpfennig@dfci.harvard.edu.

Abstract

It will soon be 50 years since the first MHC associations with human disease were described. These seminal studies opened a flourishing area of research, yet much remains to be discovered. Genome-wide association studies of autoimmune diseases have demonstrated that the MHC region has effect sizes that supersede those for any non-MHC locus for most diseases. Thus, an understanding of how particular MHC alleles confer susceptibility will be essential for a comprehensive understanding of autoimmune disease pathogenesis. Here we review recent exciting findings in this important field.

PMID:
25216261
PMCID:
PMC4254370
DOI:
10.1016/j.coi.2014.08.005
[Indexed for MEDLINE]
Free PMC Article

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