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J Cell Mol Med. 2014 Nov;18(11):2135-46. doi: 10.1111/jcmm.12365. Epub 2014 Sep 12.

Anchored protein kinase A signalling in cardiac cellular electrophysiology.

Author information

1
Division of Heart & Lungs, Dept of Medical Physiology, University Medical Centre Utrecht, Utrecht, The Netherlands; Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.

Abstract

The cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac function. Substantial research in recent years has highlighted the importance of A-kinase anchoring proteins (AKAP) therein as they act as the backbones of major macromolecular signalling complexes of the β-adrenergic/cAMP/PKA pathway. This review discusses the role of AKAP-associated protein complexes in acute and chronic cardiac modulation by dissecting their role in altering the activity of different ion channels, which underlie cardiac action potential (AP) generation. In addition, we review the involvement of different AKAP complexes in mechanisms of cardiac remodelling and arrhythmias.

KEYWORDS:

AKAPs; PKA; beta adrenergic signalling; signal transduction

PMID:
25216213
PMCID:
PMC4224547
DOI:
10.1111/jcmm.12365
[Indexed for MEDLINE]
Free PMC Article

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