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Science. 2014 Sep 12;345(6202):1299-301. doi: 10.1126/science.1254163.

Antibiotic effectiveness: balancing conservation against innovation.

Author information

1
Center for Disease Dynamics, Economics & Policy, Washington, DC, USA; Princeton Environmental Institute, Princeton, NJ, USA; Public Health Foundation of India, New Delhi, India. ramanan@cddep.org.

Abstract

Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As with other such assets, keeping it available requires both conservation and innovation. Conservation encompasses making the best use of current antibiotic effectiveness by reducing demand through vaccination, infection control, diagnostics, public education, incentives for clinicians to prescribe fewer antibiotics, and restrictions on access to newer, last-resort antibiotics. Innovation includes improving the efficacy of current drugs and replenishing effectiveness by developing new drugs. In this paper, I assess the relative benefits and costs of these two approaches to maintaining our ability to treat infections.

PMID:
25214620
DOI:
10.1126/science.1254163
[Indexed for MEDLINE]

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