Format

Send to

Choose Destination
JACC Cardiovasc Imaging. 2014 Sep;7(9):920-6. doi: 10.1016/j.jcmg.2014.03.017.

Pressure fields by flow-sensitive, 4D, velocity-encoded CMR in patients with aortic coarctation.

Author information

1
German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany.
2
German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany; Institute of Biophysics and Biomedical Engineering, Faculty of Sciences of the University of Lisbon, Lisbon, Portugal.
3
Fraunhofer MEVIS, Bremen, Germany.
4
Biofluid Mechanics Laboratory, Charité-Universitätsmedizin Berlin, Berlin, Germany.
5
Institute of Biometry and Medical Informatics, University of Magdeburg, Magdeburg, Germany.
6
German Heart Institute Berlin, Unit of Cardiovascular Imaging, Department of Congenital Heart Disease and Pediatric Cardiology, Berlin, Germany. Electronic address: kuehne@dhzb.de.

Erratum in

  • JACC Cardiovasc Imaging. 2014 Nov;7(11):1183. Henneumuth, Anja [corrected to Hennemuth, Anja].

Abstract

This study compared pressure fields by 4-dimensional (4D), velocity-encoded cine (VEC) cardiac magnetic resonance imaging (CMR) with pressures measured by the clinical gold standard catheterization. Thirteen patients (n = 7 male, n = 6 female) with coarctation were studied. The 4D-VEC-CMR pressure fields were computed by solving the Pressure-Poisson equation. The agreement between catheterization and CMR-based methods was determined at 5 different measurement sites along the aorta. For all sites, the correlation coefficients between measures varied between 0.86 and 0.97 (p < 0.001). The Bland-Altman test showed good agreement between peak systolic pressure gradients across the coarctation. The nonsignificant (p > 0.2) bias was +2.3 mm Hg (± 6.4 mm Hg, 2 SDs) for calibration with dynamic pressures and +1.5 mm Hg (± 4.6 mm Hg, 2 SDs) for calibration with static pressure. In a clinical setting of coarctation, pressure fields can be accurately computed from 4D-VEC-CMR-derived flows. In patients with coarctation, this noninvasive technique might evolve to an alternative to invasive catheterization.

KEYWORDS:

cardiac magnetic resonance; catheterization; coarctation; pressure

Comment in

PMID:
25212797
DOI:
10.1016/j.jcmg.2014.03.017
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center