Format

Send to

Choose Destination
Biomolecules. 2014 Sep 10;4(3):827-47. doi: 10.3390/biom4030827.

The 26S proteasome and initiation of gene transcription.

Author information

1
Department of Biological Chemistry, University of California, Irvine, CA 92697, USA. gduraira@uci.edu.
2
Department of Biological Chemistry, University of California, Irvine, CA 92697, USA. pkaiser@uci.edu.

Abstract

Transcription activation is the foremost step of gene expression and is modulated by various factors that act in synergy. Misregulation of this process and its associated factors has severe effects and hence requires strong regulatory control. In recent years, growing evidence has highlighted the 26S proteasome as an important contributor to the regulation of transcription initiation. Well known for its role in protein destruction, its contribution to protein synthesis was initially viewed with skepticism. However, studies over the past several years have established the proteasome as an important component of transcription initiation through proteolytic and non-proteolytic activities. In this review, we discuss findings made so far in understanding the connections between transcription initiation and the 26S proteasome complex.

PMID:
25211636
PMCID:
PMC4192674
DOI:
10.3390/biom4030827
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center